Tag: application of biology in therapy and vaccine

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Multiple choice zoology applications of biotechnology gene therapy application of biology in therapy and vaccine gene cloning

"Introduction of a normal functional gene into cells, in order to replace defective or mutated gene'." is known as 

  1. Biosafety

  2. Biopiracy

  3. Biopatent

  4. Gene therapy
Reveal answer Fill a bubble to check yourself
D Correct answer
Explanation

Introduction of a normal functional gene into cells, in order to replace defective or mutated gene is known as gene therapy. It is also called as gene transfer. It is done to correct genetic disorders. Biosafety is the prevention of large-scale loss of biological integrity. Biopiracy is the practice of exploiting indigenous knowledge of nature, originating with indigenous peoples without compensation to the indigenous people. Biopatent is a patent granted by the government to the inventor of biological entities.

Thus, the correct answer is 'Gene therapy.'

Multiple choice zoology applications of biotechnology gene therapy application of biology in therapy and vaccine gene cloning

a functional ADAcDNA can be introduced into cells of the patients receiving gene therapy by using vector constituted by

  1. E.coil

  2. Reoviridae

  3. Retrovirus

  4. Agrobacterium
Reveal answer Fill a bubble to check yourself
A Correct answer
Explanation
The deficiency of the purine salvage enzyme adenosine deaminase is associated with severe B and T-cell dysfunction. In order to investigate the ADA molecule, gene therapy using E.coli, cDNA clones encoding ADA gene sequences are obtained.
So the correct option is 'E.coli'.
Multiple choice zoology applications of biotechnology gene therapy application of biology in therapy and vaccine gene cloning

Cystic fibrosis can be treated by .......... gene therapy.

  1. TGP-B

  2. TPA

  3. DNase

  4. BGH
Reveal answer Fill a bubble to check yourself
C Correct answer
Explanation

DNase (Deoxyribonuclease) is used in cystic fibrosis treatment to break down the thick mucus in the lungs, which is rich in DNA from dead white blood cells. While gene therapy is a research area for cystic fibrosis, DNase is the standard pharmacological treatment listed.

Multiple choice zoology applications of biotechnology genetically engineered insulin application of biology in therapy and vaccine application of biotechnology in medicine

Insulin has 51 amino acids arranged in

  1. Single polypeptide

  2. Two polypeptides of 21 and 30 amino acids

  3. Two polypeptides of 25 and 26 amino acids

  4. Three polypeptides having 15, 16 and 20 amino acids
Reveal answer Fill a bubble to check yourself
B Correct answer
Explanation

Insulin consists of two polypeptide chains: the A-chain (21 amino acids) and the B-chain (30 amino acids), linked by disulfide bridges.

Multiple choice zoology applications of biotechnology genetically engineered insulin application of biology in therapy and vaccine application of biotechnology in medicine

After removal of signal peptide, the secretory protein involved in formation of insulin is known as

  1. Preinsulin

  2. Proinsulin

  3. Postinsulin

  4. Prepinsulin
Reveal answer Fill a bubble to check yourself
B Correct answer
Explanation

The insulin mRNA is translated as a single chain precursor called preproinsulin, and removal of its signal peptide during insertion into the endoplasmic reticulum generates proinsulin. Insulin and free C peptide are packaged in the Golgi into secretory granules which accumulate in the cytoplasm.

So, the correct answer is 'Proinsulin.'

Multiple choice zoology applications of biotechnology genetically engineered insulin application of biology in therapy and vaccine application of biotechnology in medicine

Assertion: Humilin synthesizes in the form of proinsulin.

Reason: C - peptide is not seen in mature insulin.

  1. A and R both are correct. Where R is explanation of A

  2. A and R both are correct. Where R is not explanation of A

  3. A is correct white R is correct

  4. A is incorrect white R is correct
Reveal answer Fill a bubble to check yourself
A Correct answer
Explanation

Insulin in human body is synthesized in the form of proinsulin . Proinsulin is a molecule which has 24 amino acids , B-chain peptide , C-chain peptide and A-chain peptide . The C-chain peptide of precursor insulin molecule has two amino acids . In mature insulin the C-chain peptide is cleaved off which results in the joining of A-chain peptide and B-chain peptide and form its active form. 

So the correct answer is ' A and R both are correct . Where R is the explanation of A ' .

Multiple choice zoology applications of biotechnology genetically engineered insulin application of biology in therapy and vaccine application of biotechnology in medicine

Genetically engineered human insulin is called as

  1. Humulin

  2. Haematin

  3. Hybridoma

  4. Hybrid
Reveal answer Fill a bubble to check yourself
A Correct answer
Explanation

Humulin is the genetically engineered insulin produced by inserting human insulin gene into a host cell (E. coli) which was then allowed to grow and reproduce normally. The inserted human DNA lead them to produce a synthetic version of human insulin. Hybrid is a offspring of two genetically dissimilar animals or plants which carries genetic material from both parents and express new specific genetic characteristics. The dark bluish or brownish pigment obtained by the oxidation of haeme that has contain iron in the ferric state is known as haematin. Hybridomas are the hybrids produced by introducing specific antigen into a mouse to collect antibody-producing cells. These cells are then fused with myeloma cell to produce hybridomas which multiply indefinitely and thus provide infinite source of a specific antibody. 

Multiple choice zoology applications of biotechnology genetically engineered insulin application of biology in therapy and vaccine application of biotechnology in medicine

Diabetes is caused due to the deficiency of insulin in the blood.

  1. True

  2. False
Reveal answer Fill a bubble to check yourself
A Correct answer
Explanation
  • Diabetes is a disease in which your blood glucose, or blood sugar, levels are too high.
  • Glucose comes from the foods you eat. Insulin is a hormone secreted by the pancreas that helps the glucose get into your cells to give them energy. With type 1 diabetes, your body does not make insulin.
  • Hence diabetes is caused due to the deficiency of insulin in the blood is a true statement.
  • So, the correct answer is 'True'.