Tag: application of biology in therapy and vaccine

Questions Related to application of biology in therapy and vaccine

Which vector is used to replace defective gene in gene therapy?

zoology genetics of the future gene therapy application of biology in therapy and vaccine gene cloning

  1. Cosmid

  2. Ri plasmid

  3. Ti plasmid

  4. Adenovirus

Show answer
Correct Option: D
Assertion : Genital herpes cannot be cured if recurrent.
Reason : Genital herpes can be inhibited by acyclovir.
zoology genetics of the future gene therapy application of biology in therapy and vaccine gene cloning

  1. Both the Assertion and the Reason are true and the Reason is a correct explanation of the Assertion.

  2. Both the Assertion and Reason are true but the Reason is not a correct explanation of the Assertion.

  3. The Assertion is true but the Reason is false.

  4. Both the Assertion and Reason are false.

  5. The Assertion is false but Reason is true.

Show answer
Correct Option: B
Explanation:

An antiviral drug is used to treat genital herpes outbreaks stay symptom-free longer. These drugs can also reduce the severity and duration of symptoms when they do flare up. Drug therapy is not a cure, but it can make living with the condition easier. Because of lack of research about the Herpes virus action mechanism, there is no cure for Herpes but it is inhibited by acyclovir. It is one of the most common sexually transmitted infections. 

Which of these is used as vector for gene therapy in SCID and gene cloning in higher organisms?

zoology genetics of the future gene therapy application of biology in therapy and vaccine gene cloning

  1. Retrovirus

  2. Enterovirus

  3. Arbovirus

  4. Rotavirus

  5. Parvovirus

Show answer
Correct Option: A

Enzyme adenosine deaminase is deficient in .......... genetic disorder.

zoology genetics of the future gene therapy application of biology in therapy and vaccine gene cloning

  1. Alzheimers disease

  2. Muscular dystrophy

  3. SCID

  4. Colour blindness

Show answer
Correct Option: C
Explanation:

The correct option is C


Severe combined immunodeficiency (SCID) is an X-limbed inherited disorder of the immune system, that occurs almost exclusively in males. Boys with x-linked SCID are prone to recurrent and persistent infections because they 
lack the necessary immune cells to fight off certain bacteria, viruses, etc, It is 
caused by a disorder of or by a deficiency of the adenosine deaminase which is very necessary for lymphocyte development.

First clinical application of gene therapy was used in 1992 over a four year old girl for

zoology genetics of the future gene therapy application of biology in therapy and vaccine gene cloning

  1. Adenosine deficiency

  2. Adenine deficiency

  3. Growth deficiency

  4. Adenosine deaminase deficiency

Show answer
Correct Option: D

The genetic defect adenosine deaminase (ADA) deficiency may be cured permanently by

zoology genetics of the future gene therapy application of biology in therapy and vaccine gene cloning

  1. Introducing bone marrow cells producing (ADA) into cells at an early embryonic stage.

  2. Administrating adenosine deaminase activators.

  3. Periodic infusion of genetically engineered lymphocytes having functional ADA cDNA.

  4. Enzyme replacement therapy.

Show answer
Correct Option: A

A genetic disorder can be cured through 

zoology genetics of the future gene therapy application of biology in therapy and vaccine gene cloning

  1. Gene therapy

  2. rDNA technology

  3. Embryo transfer

  4. Hybridoma technology

Show answer
Correct Option: A

Due to .......... therapy changes would be heritable.

zoology genetics of the future gene therapy application of biology in therapy and vaccine gene cloning

  1. Magnetic therapy

  2. Somatic cell gene therapy

  3. Germ line gene therapy

  4. Chemotherapy

Show answer
Correct Option: C
Explanation:
Gene therapy is treating the diseases by modifying the gene expression or inserting the deficient gene therapeutically into the patients cells. Gene therapy is of two types, somatic gene therapy and germline gene therapy.
In somatic gene therapy, gene manipulation is done in the cells which will affect the patient but it will not be inherited. In germline gene therapy, gene manipulation is done in the germ cells or the gametes that will be used to conceive. The modified germ cells will produce the gametes having the inserted gene and on fertilisation will produce a zygote that will form the individual in which each and every cell will have the manipulated gene, because every cell descendes from the zygote. Thus, the changes will be heritable.
So, the correct answer is C.

Gene therapy is treatment done on

zoology genetics of the future gene therapy application of biology in therapy and vaccine gene cloning

  1. Adults only

  2. Child or embryo only

  3. Pregnant mothers only

  4. Persons of any age and condition

Show answer
Correct Option: D

Which of the following statements is incorrect about gene therapy in ADA deficiency?

zoology genetics of the future gene therapy application of biology in therapy and vaccine gene cloning

  1. Lymphocytes from patient's blood are taken out and cultured.

  2. A functional ADA cDNA is introduced into these lymphocytes.

  3. Lymphocytes are then introduced in the body of patient.

  4. Patient does not require periodic infusion of genetically engineered lymphocytes.

Show answer
Correct Option: D
Explanation:
As a first step towards gene therapy, lymphocytes from the blood of the patient are grown in a culture outside the body. A functional ADA-cNDA  (using a retroviral vector) is then introduced into these lymphocytes, which are subsequently returned to the body of the patient. However, as these cells are not immortal, the patient requires periodic infusion of such genetically engineered lymphocytes.
So, the correct answer is 'Patient does not require periodic infusion of genetically engineered lymphocytes'.