Tag: gene therapy

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Questions Related to gene therapy

Multiple choice zoology genetics of the future gene therapy application of biology in therapy and vaccine gene cloning

Somatic gene therapy causes ___________.

  1. Changes in sperm

  2. Changes in progeny

  3. Changes in body cell

  4. Changes in ovum
Reveal answer Fill a bubble to check yourself
C Correct answer
Explanation

Somatic gene therapy involves the introduction of genes into the somatic cells of an individual, meaning the genetic changes affect only that patient and are not passed on to their offspring, sperm, or ova.

Multiple choice zoology genetics of the future gene therapy application of biology in therapy and vaccine gene cloning

SCID is caused by defective gene coding for enzyme ______________.

  1. Adenosine deaminase

  2. Adenosine transaminase

  3. Adenosine transferase

  4. Guanosine transaminaseGuanosine deaminase
Reveal answer Fill a bubble to check yourself
A Correct answer
Explanation

Adenosine deaminase deficiency SCID, commonly called ADA SCID, is a very rare genetic disorder. It is caused by a mutation in the gene that encodes a protein called adenosine deaminase (ADA). 

Multiple choice zoology genetics of the future gene therapy application of biology in therapy and vaccine gene cloning
Assertion : Genital herpes cannot be cured if recurrent.
Reason : Genital herpes can be inhibited by acyclovir.

  1. Both the Assertion and the Reason are true and the Reason is a correct explanation of the Assertion.

  2. Both the Assertion and Reason are true but the Reason is not a correct explanation of the Assertion.

  3. The Assertion is true but the Reason is false.

  4. Both the Assertion and Reason are false.

  5. The Assertion is false but Reason is true.
Reveal answer Fill a bubble to check yourself
B Correct answer
Explanation

An antiviral drug is used to treat genital herpes outbreaks stay symptom-free longer. These drugs can also reduce the severity and duration of symptoms when they do flare up. Drug therapy is not a cure, but it can make living with the condition easier. Because of lack of research about the Herpes virus action mechanism, there is no cure for Herpes but it is inhibited by acyclovir. It is one of the most common sexually transmitted infections. 

Multiple choice zoology genetics of the future gene therapy application of biology in therapy and vaccine gene cloning

Which of these is used as vector for gene therapy in SCID and gene cloning in higher organisms?

  1. Retrovirus

  2. Enterovirus

  3. Arbovirus

  4. Rotavirus

  5. Parvovirus
Reveal answer Fill a bubble to check yourself
A Correct answer
Explanation

Retroviruses are frequently used as vectors in gene therapy, particularly for SCID (Severe Combined Immunodeficiency), because they can integrate their genetic material into the host genome.

Multiple choice zoology genetics of the future gene therapy application of biology in therapy and vaccine gene cloning

Enzyme adenosine deaminase is deficient in .......... genetic disorder.

  1. Alzheimers disease

  2. Muscular dystrophy

  3. SCID

  4. Colour blindness
Reveal answer Fill a bubble to check yourself
C Correct answer
Explanation

The correct option is C


Severe combined immunodeficiency (SCID) is an X-limbed inherited disorder of the immune system, that occurs almost exclusively in males. Boys with x-linked SCID are prone to recurrent and persistent infections because they 
lack the necessary immune cells to fight off certain bacteria, viruses, etc, It is 
caused by a disorder of or by a deficiency of the adenosine deaminase which is very necessary for lymphocyte development.

Multiple choice zoology genetics of the future gene therapy application of biology in therapy and vaccine gene cloning

First clinical application of gene therapy was used in 1992 over a four year old girl for

  1. Adenosine deficiency

  2. Adenine deficiency

  3. Growth deficiency

  4. Adenosine deaminase deficiency
Reveal answer Fill a bubble to check yourself
D Correct answer
Explanation

The first successful gene therapy trial in 1990 (often cited as 1992 in some texts) was performed on Ashanthi DeSilva for Adenosine Deaminase (ADA) deficiency.

Multiple choice zoology genetics of the future gene therapy application of biology in therapy and vaccine gene cloning

The genetic defect adenosine deaminase (ADA) deficiency may be cured permanently by

  1. Introducing bone marrow cells producing (ADA) into cells at an early embryonic stage.

  2. Administrating adenosine deaminase activators.

  3. Periodic infusion of genetically engineered lymphocytes having functional ADA cDNA.

  4. Enzyme replacement therapy.
Reveal answer Fill a bubble to check yourself
A Correct answer
Explanation

Permanent cure for ADA deficiency involves introducing functional ADA genes into bone marrow stem cells at an early stage, allowing the body to produce its own functional enzyme.

Multiple choice zoology genetics of the future gene therapy application of biology in therapy and vaccine gene cloning

Due to .......... therapy changes would be heritable.

  1. Magnetic therapy

  2. Somatic cell gene therapy

  3. Germ line gene therapy

  4. Chemotherapy
Reveal answer Fill a bubble to check yourself
C Correct answer
Explanation
Gene therapy is treating the diseases by modifying the gene expression or inserting the deficient gene therapeutically into the patients cells. Gene therapy is of two types, somatic gene therapy and germline gene therapy.
In somatic gene therapy, gene manipulation is done in the cells which will affect the patient but it will not be inherited. In germline gene therapy, gene manipulation is done in the germ cells or the gametes that will be used to conceive. The modified germ cells will produce the gametes having the inserted gene and on fertilisation will produce a zygote that will form the individual in which each and every cell will have the manipulated gene, because every cell descendes from the zygote. Thus, the changes will be heritable.
So, the correct answer is C.