Tag: gene therapy

Quizzes (0) Questions (36)

Questions Related to gene therapy

Multiple choice zoology genetics of the future gene therapy application of biology in therapy and vaccine gene cloning

Gene therapy is treatment done on

  1. Adults only

  2. Child or embryo only

  3. Pregnant mothers only

  4. Persons of any age and condition
Reveal answer Fill a bubble to check yourself
D Correct answer
Explanation

Gene therapy can theoretically be applied to patients of any age, although the type of therapy (somatic vs germline) and the specific condition dictate the feasibility and ethical considerations.

Multiple choice zoology genetics of the future gene therapy application of biology in therapy and vaccine gene cloning

Which of the following statements is incorrect about gene therapy in ADA deficiency?

  1. Lymphocytes from patient's blood are taken out and cultured.

  2. A functional ADA cDNA is introduced into these lymphocytes.

  3. Lymphocytes are then introduced in the body of patient.

  4. Patient does not require periodic infusion of genetically engineered lymphocytes.
Reveal answer Fill a bubble to check yourself
D Correct answer
Explanation
As a first step towards gene therapy, lymphocytes from the blood of the patient are grown in a culture outside the body. A functional ADA-cNDA  (using a retroviral vector) is then introduced into these lymphocytes, which are subsequently returned to the body of the patient. However, as these cells are not immortal, the patient requires periodic infusion of such genetically engineered lymphocytes.
So, the correct answer is 'Patient does not require periodic infusion of genetically engineered lymphocytes'.
Multiple choice zoology genetics of the future gene therapy application of biology in therapy and vaccine gene cloning

Identify the wrong statements :


a) Genetic modifications in plants helped to reduce post-harvest losses
b) In Tobacco, cry genes are introduced against nematodes
c) In gene therapy, healthy genes are inserted into persons cells and tissues to treat diseases
d) Injustice, inadequate compensation, and benefit-sharing are related to molecular diagnosis

  1. a, b, c

  2. b, c, d

  3. a, b, d

  4. a, c, d
Reveal answer Fill a bubble to check yourself
B Correct answer
Explanation

Statement (b) is incorrect because cry genes are used against insects/pests, not nematodes. Statement (d) regarding injustice and benefit-sharing is related to biopiracy and ethical issues in biotechnology, not specifically molecular diagnosis.

Multiple choice zoology genetics of the future gene therapy application of biology in therapy and vaccine gene cloning

Adenosine deaminase deficiency can be permanently cured by which of the following methods?

  1. Bone marrow transplantation

  2. Enzymes replacement therapy

  3. Gene therapy at early embryonic stages

  4. All of these
Reveal answer Fill a bubble to check yourself
C Correct answer
Explanation

Adenosine deaminase (ADA) deficiency can be treated by bone marrow transplantation, or by enzyme replacement therapy, in which functional ADA is given to the patient by injection. But permanent treatment can be done by introduction of gene isolated from bone marrow cells, which produces ADA, into the cells of the patient at early embryonic stage.

Multiple choice zoology genetics of the future gene therapy application of biology in therapy and vaccine gene cloning

..........is the transfer of normal genes into body cells to correct a genetic defect.

  1. gene therapy

  2. gene mutation

  3. nucleic acid hybridization

  4. reverse transcription
Reveal answer Fill a bubble to check yourself
A Correct answer
Explanation

Gene therapy is a collection of methods that allow correction of a gene defect that has been diagnosed in a child/embryo. In this method, genes are inserted into a person's cells and tissues to treat a disease. Correction of a genetic defect involves delivery of a normal gene into the individual or embryo to take over the function of and compensate for the non-functional gene.

So, the correct option is 'gene therapy'.

Multiple choice zoology genetics of the future gene therapy application of biology in therapy and vaccine gene cloning

Gene therapy has been successful in curing genetic diseases in laboratory animals through

  1. Exposure to X-ray to rectify the defective gene

  2. Replacing the defective gene with a functional gene

  3. Oral delivery of genes

  4. Use of therapeutic medicines to rectify the defective genes
Reveal answer Fill a bubble to check yourself
B Correct answer
Explanation

The fundamental principle of gene therapy is to replace a defective or missing gene with a functional copy to restore normal cellular function.

Multiple choice zoology genetics of the future gene therapy application of biology in therapy and vaccine gene cloning

The first clinical gene therapy was done for the treatment of __________.

  1. AIDS

  2. Cancer

  3. Cystic fibrosis

  4. SCID (Serve Combined Immuno Deficiency resulting form deficiency of ADA)
Reveal answer Fill a bubble to check yourself
D Correct answer
Explanation

The first clinical gene therapy was given in 1990 to a 4-years old girl with adenosine deaminase (ADA) deficiency. This enzymes is very important for the immune system to function. ADA deficiency can lead to severe combined immune deficiency (SCID). 

Multiple choice zoology genetics of the future gene therapy application of biology in therapy and vaccine gene cloning

Diseases that are caused by the malfunction of a phototropic gene are:

  1. Cured by dietary restrictions

  2. Reversible by gene therapy

  3. Called as syndromes

  4. Extremely rare
Reveal answer Fill a bubble to check yourself
B Correct answer
Explanation
Phototropism is the growth of an organism which responds to a light stimulus. It is most often observed in plants, but can also occur in other organisms such as fungi. The cells on the plant that are farthest from the light have a chemical called auxin that reacts when phototropism occurs. Gene therapy is an experimental technique that uses genes to treat or prevent disease. In the future, this technique may allow doctors to treat a disorder by inserting a gene into a patient's cells instead of using drugs or surgery. 
So the correct option is 'Reversible by gene therapy'.
Multiple choice zoology genetics of the future gene therapy application of biology in therapy and vaccine gene cloning

Which of the following statements regarding gene therapy is/are correct? 

  1. It is an application of biotechnology, in which a defective gene is manipulated by introduction of a normal, healthy and functional gene.

  2. The genetic disorders that are being investigated for gene therapy, range from sickle-cell anemia to server combined immuno-deficiency (SCDI).

  3. The first clinical gene therapy was given in 1990 to a 4-year old girl with adenosine deaminase (ADA) deficiency.

  4. All of the above
Reveal answer Fill a bubble to check yourself
D Correct answer
Explanation
Gene therapy is a technique for correcting defective genes responsible for disease development. Under intensive investigation are, disease ranging from the rare genetic diseases caused by single mutations like sickle cell anaemia to killer diseases such as server combined immuno-deficiency (SCID). The first clinical gene therapy was given in 1990 to a 4-years old girl with adenosine deaminase (ADA) deficiency. This enzymes is very important for the immune system to function. ADA deficiency can lead to severe combined immuno-deficiency (SCID).
So, the correct answer is 'All of the above'.