Pharmacology and Therapeutics

This is the correct answer.

This option is correct because indol-1 is a popular calcium indicator similar to fura-2. In contrast to fura-2, indol-1 has a dual emission peak in Ca free solution in 475 nm while in the presence of Ca, the emission is shifted to 400 nm.

P-glycoprotein is a multidrug resistance protein.

Lipinski's rule of five states that an orally active drug generally has no more than 5 hydrogen bond donors, 10 hydrogen bond acceptors, a molecular weight under 500, and a logP under 5.

ADME-TOX prediction tools help forecast Absorption, Distribution, Metabolism, Excretion, and Toxicity properties of drug candidates. 'ADME predictor' is the standard naming convention for such tools.

De novo drug design involves building drug molecules atom-by-atom or from fragments to fit a specific receptor binding site, unlike docking which studies existing molecules or QSAR which uses statistical correlations.

Chlorotrianisene is a non-steroidal synthetic estrogen that was formerly used for the treatment of menopause, deficiencies in ovary function and prostate cancer. Diethylstilbestrol is a synthetic non-steroidal estrogen that was first synthesised in 1938. Fosfestrol is a synthetic estrogen used as an antineoplastic agent.

This option is correct because Ephedra species produce the alkaloid ephedrine, which is used in various medications and the cancer treatment drug topotecan is an extract of Camptotheca sp.

Two chemotherapy drugs, etoposide and teniposide, are derived from toxins found in Podophyllum peltatum. Pacitaxel is an anticancer drug that is obtained from Taxus brevifolia.

The indigenous medicinal plant, Adhatoda vasica, commonly known as vasaka, is used as a herbal remedy for allergen-induced bronchial obstruction, asthma and tuberculosis. It contains Vasicine alkaloid.

The Pyrethrins are a pair of natural organic compounds, which are normally derived from Chrysanthemum cinerariifolium that have potent insecticidal activity. The alkaloid solanine is derived from unripe fruits of Solanum dulcamara and showed antidermatophytic activity against Chrysosporium indicum.

Correct answer. Diethylstilbestrol is a synthetic nonsteroidal estrogen that was first synthesised in 1938. Fosfestrol is a synthetic estrogen used as an antineoplastic agent.

Correct answer. Chlorotrianisene is a non-steroidal synthetic estrogen that was formerly used for the treatment of menopause, deficiencies in the functioning of ovaries and prostate cancer. Diethylstilbestrol is a synthetic nonsteroidal estrogen that was first synthesised in 1938. Fosfestrol is a synthetic estrogen used as an antineoplastic agent.

This is an anti-inflammatory drug. 

This is the correct option.