Biology
Human Immunity and Blood
2,096 Questions
Human immunity and blood questions cover the physiological mechanisms protecting the body against diseases and the components of blood. Topics include blood groups, cell mediated immunity, monoclonal antibodies, and blood coagulation. These biology topics frequently appear in general science sections of competitive exams.
Blood groupsCell mediated immunityMonoclonal antibodiesBlood coagulationCancer immunology
Human Immunity and Blood Questions
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Bone marrow
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Brain
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Lymph node
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Blood cells
A
Correct answer
Explanation
Leukemia is a cancer of blood-forming tissues, primarily originating in bone marrow where abnormal white blood cells are produced. While it affects blood cells, the root cause and primary site is bone marrow dysfunction.
D
Correct answer
Explanation
AB blood group is the universal recipient because it has both A and B antigens on red blood cells but no anti-A or anti-B antibodies in plasma. This allows AB individuals to receive blood from any ABO group (A, B, AB, or O) without antibody-mediated rejection. Types A, B, and O can only receive from their own type or O (universal donor).
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NK cells have rearranged T-cell receptor genes.
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NK cells are unaffected by IFN alpha.
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NK cells are more active against targets with upregulated MHC class I.
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NK cells can kill certain virally-infected cells.
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NK cells can kill all virally-infected cells.
D
Correct answer
Explanation
Like cytotoxic T-cells, NK cells can inhibit viral replication by killing the host cell. The difference is that cytotoxic T-cells have a receptor for a specific T-cell epitope whereas NK cells have a broader specificity.
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Microglial cells
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Kupffer cells
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Alveolar macrophages
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Langerhans cells
B
Correct answer
Explanation
These amoeboid cells are found in the liver sinusoid and help to remove the toxic material from blood.
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Plasma
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Red blood cells
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White blood cells
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Haemoglobin
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Platelets
D
Correct answer
Explanation
Haemoglobin is the red pigment that gives the red blood cells their colour.
This is the correct answer. Platelets help in the blood clotting during cuts or wounds.
C
Correct answer
Explanation
Veiled cells are immature dendritic cells found in blood.
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Development of B and T lymphocytes
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Attraction of lymphocytes to infected site
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Chemoattractant
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Inflammation
D
Correct answer
Explanation
sPLA2 (Secreted phospholipases A2) have been shown to promote inflammation in mammals by catalysing the first step of the arachidonic acid pathway by breaking down phospholipids.
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C4a and C5a
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C4b and C3b
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C4a and C3a
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C5a and C6-C9
B
Correct answer
Explanation
C3b and, to a lesser degree, C4b molecules are opsonins.
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anaphylotoxin
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opsonin
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control protein
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decay accelerating factor (DAF)
C
Correct answer
Explanation
Factor H is a member of complement activation family.
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IgA antibodies
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IgE antibodies
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IgM antibodies
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IgD antibodies
B
Correct answer
Explanation
Mast cells express a high-affinity receptor (FcεRI) for the Fc region of IgE antibodies.
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basophils
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neutrophils
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eosinophils
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monocytes
B
Correct answer
Explanation
MPOs are expressed in neutrophil granulocytes.
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Class I HLA
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Class II HLA
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Class III HLA
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Class IV HLA
B
Correct answer
Explanation
Class II HLA are membrane-bound glycoproteins that are restricted to macrophages and lymphocytes.
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R.B.C.
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Lymphocytes
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Monocytes
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Platelets
D
Correct answer
Explanation
Platelets (thrombocytes) are the blood components responsible for clotting - they gather at wound sites, release clotting factors, and form platelet plugs. RBCs carry oxygen, lymphocytes are white blood cells for immunity, and monocytes are also white blood cells that fight infection but don't directly clot blood.
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only group B
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only group AB
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only group A
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any blood group
D
Correct answer
Explanation
The correct answer is 'any blood group' because persons with blood group AB are called 'universal recipients' - they have both A and B antigens on their red blood cells and no anti-A or anti-B antibodies. This means they can safely receive blood from any blood group (A, B, AB, or O) without having a transfusion reaction.
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Red blood cells
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Plasma
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White blood cells
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Hemoglobin
C
Correct answer
Explanation
The correct answer is white blood cells (leukocytes), which are the cells in the human body that fight infection. They are part of the immune system. Red blood cells carry oxygen, plasma is the fluid component, and hemoglobin is the oxygen-carrying protein in red blood cells.