Multiple choice

Deletions in the T-cell CD154 (CD40L) gene produces which of the following?

  1. Congenital X-linked agammaglobulinemia

  2. IgA deficiency

  3. Wiskott–Aldrich Syndrome

  4. Deficiency in cytotoxic T-cell activity

  5. The hyper–IgM syndrome

Reveal answer Fill a bubble to check yourself
E Correct answer
Explanation

Lack of CD154 (CD40L) prevents signalling to the B-cell CD40 to bring about Ig class-switching away from IgM.