Multiple choice

Doctor told Aruna that her father is suffering from a disease which occurs due to the deletions in T-cell CD154 (CD40L) gene. Which among the following diseases must the doctor be referring to?

  1. Hyper–IgM syndrome

  2. Congenital X-linked agammaglobulinemia

  3. IgA deficiency

  4. Wiskott–Aldrich syndrome

  5. Deficiency in cytotoxic T-cell activity

Reveal answer Fill a bubble to check yourself
A Correct answer
Explanation

Lack of CD154 (CD40L) prevents signalling to the B-cell CD40 to bring about Ig class-switching away from IgM.