Multiple choice

A doctor told a couple that their son is suffering from a disease resulting from the deletions in the T-cell CD154 (CD40L) gene. Which of the following diseases must the doctor be referring to?

  1. Hyper-IgM syndrome

  2. Congenital X-linked agammaglobulinemia

  3. IgA deficiency

  4. Wiskott-Aldrich syndrome

  5. Deficiency in cytotoxic T-cell activity

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A Correct answer
Explanation

Lack of CD154 (CD40L) prevents signalling to the B-cell CD40 to bring about Ig class-switching away from IgM.