Biology

Molecular Biology and Genetics

985 Questions

Molecular biology and genetics explore the structure and function of DNA, RNA, genetic mutations, and heredity. Understanding these building blocks of life is essential for most biology examinations. Review these practice questions to test your molecular genetics knowledge.

DNA structure and basesGenetic mutationsNucleic acids compositionDNA sequencing and replication

Molecular Biology and Genetics Questions

Multiple choice
  1. positively charged

  2. negatively charged

  3. amphoteric

  4. neutral

  5. Zwitterions

Reveal answer Fill a bubble to check yourself
B Correct answer
Explanation

Phosphoryl groups of nucleotides furnish H+ ions at physiological pH and thus leave nucleotides negatively charged.

Multiple choice
  1. Aminopterin

  2. Hypoxanthine

  3. Thymidine

  4. Both 2 and 3

  5. Rayon acetate

Reveal answer Fill a bubble to check yourself
A Correct answer
Explanation

The antimetabolite aminopterin blocks the cellular biosynthesis of purines and pyrimidines from simple sugars and amino acids while HGPRT and TK supply them from hypoxanthine and thymidine.

Multiple choice
  1. Protein Data Bank

  2. Crystallographic database

  3. Protein structure database

  4. ProtCID

  5. CASP

Reveal answer Fill a bubble to check yourself
A Correct answer
Explanation

The Protein Data Bank (PDB) is a crystallographic database for the three-dimensional structural data of large biological molecules, such as proteins and nucleic acids.

Multiple choice
  1. Protein subcellular localization prediction

  2. PROSITE

  3. SIMAP

  4. BOINC

  5. VENN

Reveal answer Fill a bubble to check yourself
B Correct answer
Explanation

PROSITE is a protein database. It consists of entries describing the protein families, domains and functional sites as well as amino acid patterns and profiles in them.

Multiple choice
  1. SCOP

  2. CATH

  3. FSSP

  4. Pfam

  5. SUPERFAMILY

Reveal answer Fill a bubble to check yourself
A Correct answer
Explanation

The Structural Classification of Proteins (SCOP) database is a largely manual classification of protein structural domains based on similarities of their structures and amino acid sequences. A motivation for this classification is to determine the evolutionary relationship between proteins.

Multiple choice
  1. LOLI

  2. ChEBI

  3. BMCD

  4. SPRESI

  5. BindingDB

Reveal answer Fill a bubble to check yourself
C Correct answer
Explanation

The Biological Macromolecule Crystallization Database (BMCD) contains molecule, crystal and crystallization data for macromolecules for which diffraction quality crystals have been obtained. These include proteins and nucleic acids, various complexes, and viruses.

Multiple choice
  1. PROSITE

  2. TIGRFAMs

  3. InterPro

  4. PRINTS

  5. ProDom

Reveal answer Fill a bubble to check yourself
C Correct answer
Explanation

InterPro is a database of protein families, domains and functional sites in which identifiable features found in known proteins can be applied to new protein sequences in order to functionally characterise them.

Multiple choice
  1. BioGRID

  2. STRING

  3. Reactome

  4. SignaLink 2.0

  5. ModBase

Reveal answer Fill a bubble to check yourself
A Correct answer
Explanation

The Biological General Repository for Interaction Datasets (BioGRID) is a curated biological database of protein-protein interactions, genetic interactions, chemical interactions, and post-translational modifications created in 2003 (originally referred to as simply the General Repository for Interaction Datasets (GRID) by Mike Tyers, Bobby-Joe Breitkreutz, and Chris Stark at the Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital.