Multiple choice

Myasthenia gravis (MG) is a relatively rare autoimmune disorder in which antibodies form against acetylcholine nicotinic postsynaptic receptors. Which of the following statements about the pathogenesis of myasthenia gravis is true?

  1. Myasthenia gravis is the result of a type II immunological hypersensitivity reaction.

  2. MG is caused by antibodies directed against presynaptic calcium channel receptors.

  3. MG is never caused by therapeutic drugs.

  4. Pregnancy poses a huge risk of neonatal MG to the foetus.

  5. Extraocular muscles remains unaffected.
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A Correct answer
Explanation

Myaesthenia gravis is a type II disease of muscle end plates, due to autoantibodies against post-synaptic acetyl choline receptors. These antibodies result in lysis by complement as well as internalization of receptors after binding with the antibodies.

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