Multiple choice

A neuromuscular junction is a specialised synapse between a neuron and the muscle it innervates. Which of the following diseases is caused by auto-antibodies to voltage gated calcium channels at the presynaptic side of the neuromuscular junction that leads to a reduction in the amount of acetylcholine released from nerve terminals?

  1. Congenital myasthenia

  2. LEMS (Lambert-Eaton myasthenic syndrome)

  3. Myasthenia gravis

  4. Neuromyotonia
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B Correct answer
Explanation

Muscle weakness in LEMS is caused by auto-antibodies to voltage gated calcium channels at the presynaptic side of the neuromuscular junction.

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