Multiple choice The pathogenic autoantibody in Graves’ disease has specificity for _____________. nuclei thyroid peroxidase thyroglobulin Thyroid-stimulating hormone (TSH) receptors TSH Reveal answer Fill a bubble to check yourself D Correct answer Explanation Thyrotoxicosis is an over-active thyroid condition in which an autoantibody to the TSH receptor mimics TSH and so, increases thyroid hormone production and increases the metabolic rate.