Multiple choice

In HIV-1, the U5 region has been characterized according to functional and structural differences into several sub-regions. Which among the following region plays a role both in dimerization and genome packaging?

  1. Psi

  2. DIS

  3. PBS

  4. TAR

  5. Poly A

Reveal answer Fill a bubble to check yourself
E Correct answer
Explanation

Poly A plays a role both in dimerization and genome packaging since it is necessary for cleavage and polyadenilation. It has been reported that sequences upstream (U3 region) and downstream (U5 region) are needed in order to make the cleavage process efficient.