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Human Genetics - 2

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15 Questions Published
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Questions

Question 1 Multiple Choice (Single Answer)

Which among the following is/are used by viruses to insert their genetic material into the host genomes?

  1. Inverted repeat
  2. Direct repeats
  3. Long terminal repeats
  4. Tandem repeats
  5. Interspersed repetitive DNA elements
Question 2 Multiple Choice (Single Answer)

The inserted gene may damage the function of one of the host's genes. Which among the following insertion causes loss of protein function in host genes?

  1. Insertion between promoter and upstream enhancers
  2. Insertion in a translated region
  3. Insertion in an intron
  4. Insertion in 5' untranslated region
  5. Insertion in promoter
Question 3 Multiple Choice (Single Answer)

In HIV-1, the U5 region has been characterized according to functional and structural differences into several sub-regions. Which among the following region plays a role both in dimerization and genome packaging?

  1. Psi
  2. DIS
  3. PBS
  4. TAR
  5. Poly A
Question 4 Multiple Choice (Single Answer)

Which of the following DNA repeats encodes a RNA-binding protein of 500 amino acid lengths?

  1. SINEs
  2. UTR
  3. Second ORF
  4. First ORF
  5. LTRs
Question 5 Multiple Choice (Single Answer)

Obesity is considered to be the result of the combination of deletions, SNPs and gene mutations. Which among the following does not characterise monogenic obesity?

  1. It occurs due to the congenital leptin deficiency.
  2. The common monogenic obesity disorder was represented by excess of MC4R.
  3. The phenotype is directly and strongly related to the genotype.
  4. In leptin melanocortin pathway, leptin crosses the blood brain barrier and triggers the neurons present in the hypothalamus to generate peptides.
  5. The receptor gene mutations might be one of the reasons for severe obesity.
Question 6 Multiple Choice (Single Answer)

Which among the following is a large class of self-catalytic ribozymes?

  1. Group I introns
  2. Group II introns
  3. Twintrons
  4. LtrA
  5. Spliceosome
Question 7 Multiple Choice (Single Answer)

In genetics, the process of gene conversion is regarded as the mechanism responsible for the separation of species. Which among the following statements does not characterise gene conversion?

  1. Conversion of one allele to the other is often due to base mismatch repair during hetrozygous recombination.
  2. Meiotic recombination is initiated through formation of a double-strand break.
  3. One of these 3’ single stranded DNA segments forms an intermediate.
  4. In Synthesis Dependent Strand Annealing (SDSA), there is information exchange but not physical exchange.
  5. Gene conversion may occur during recombinational repair involving a DHJ.
Question 8 Multiple Choice (Single Answer)

A transposable element, TE is a DNA sequence that can change its position within the genome of an individual. Which among the following statements regarding the transposable element is incorrect?

  1. Mu phage transposition is the best known example of replicative transposition.
  2. A helitron is a TE found in prokaryotes.
  3. The most common form of transposable element in humans is the Alu sequence.
  4. Transposons in bacteria usually carry an additional gene for function.
  5. One family of TEs in the fruit fly Drosophila melanogaster are called P elements.
Question 9 Multiple Choice (Single Answer)

Which of the following snRNAs recognizes and binds to the sequence of the 5'-splice site of an intron in a strand of pre-mRNA?

  1. U1 spliceosomal RNA
  2. U2 spliceosomal RNA
  3. U4 spliceosomal RNA
  4. U5 spliceosomal RNA
  5. U6 spliceosomal RNA
Question 10 Multiple Choice (Single Answer)

Which among the following statements regarding the spliceosome is incorrect?

  1. Each spliceosome is composed of five small nuclear RNAs.
  2. The RNA component of the small nuclear ribonucleic protein or snRNP is rich in adenine.
  3. Introns typically have a GU nucleotide sequence at the 5' end splice site, and an AG at the 3' end splice site.
  4. A spliceosome is a large and complex molecular machine found primarily within the nucleus of eukaryotes.
  5. The spliceosome removes introns from a transcribed pre-mRNA.
Question 11 Multiple Choice (Single Answer)

Which among the following modes of alternative splicing is the rarest mode in mammals?

  1. Mutually exclusive exons
  2. Intron retention
  3. Alternative acceptor site
  4. Exon skipping or cassette exon
  5. Alternative donor site
Question 12 Multiple Choice (Single Answer)

Which of the following events does not occur in alternative splicing during gene expression?

  1. The exons to be retained in the mRNA are determined during the splicing process.
  2. U3 is not involved in mRNA splicing.
  3. Each intron has GU at its 3' end.
  4. Splicing is regulated by trans-acting proteins.
  5. Splicing silencers are sites to which splicing repressor proteins bind.
Question 13 Multiple Choice (Single Answer)

The major spliceosome splices introns containing GU at the 5' splice site and AG at the 3' splice site. At which site, the ATP gets hydrolyzed?

  1. A Complex
  2. C2 Complex
  3. C1 Complex-
  4. E Complex
  5. B2 Complex
Question 14 Multiple Choice (Single Answer)

Which among the following statements regarding the synthesis of complementary DNA (cDNA) is incorrect?

  1. A eukaryotic cell transcribes the DNA into RNA.
  2. The mixture of mature mRNA strands is extracted from the cell.
  3. A poly-T oligonucleotide primer is hybridized onto the poly-A tail of the mature mRNA template.
  4. DNA polymerase is added, along with deoxynucleotide triphosphates (A, T, G, C).
  5. It is likely that the ssDNA forms a hairpin loop at the 3' end.
Question 15 Multiple Choice (Single Answer)

The ribose moiety of which of the following nucleic acids is modified with an extra bridge connecting the 2' oxygen and 4' carbon?

  1. Xeno nucleic acid
  2. Glycol nucleic acid
  3. Threose nucleic acid
  4. A locked nucleic acid
  5. Synthetic peptide nucleic acid
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