Chemistry · Biology
Pharmacology and Therapeutics
1,643 Questions
Engage with critical pharmacology and therapeutics questions covering drug classifications and therapeutic mechanisms. Topics include chemical absorption, medication formulations, and pharmacogenomics. This collection is useful for students preparing for medical entrance, nursing, and science competitive examinations.
Chemical absorption routesDrug formulation typesMedication mechanismsEnzyme inhibitorsPharmacogenomic tests
Pharmacology and Therapeutics Questions
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Neostigmine
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Succinylcholine
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Pancuronium
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Atracurium
B
Correct answer
Explanation
Succinylcholine is the only depolarizing neuromuscular blocker among the options. It works by mimicking acetylcholine and causing persistent depolarization of the motor endplate, leading to muscle paralysis. The other options (neostigmine, pancuronium, atracurium) are non-depolarizing agents or have different mechanisms.
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Methocarbamol
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Valethamate
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Baclofen
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All of the above
D
Correct answer
Explanation
All three drugs listed are muscle relaxants. Methocarbamol is a centrally acting skeletal muscle relaxant used for muscle spasms. Valethamate (also spelled mephenesin) is a carbamate derivative muscle relaxant. Baclofen is a GABA-B agonist used for spasticity. Therefore, 'All of the above' is the correct answer.
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Counter irritants
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Rubefacients
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Piroxicams
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Diclofenacs
B
Correct answer
Explanation
Rubefacients are substances that cause redness (hyperemia) of the skin by dilating blood vessels. They work by mild irritation of the skin, increasing blood flow to the area. Counter-irritants is a broader category that includes rubefacients. Piroxicam and diclofenac are NSAIDs, not primarily used for their rubefacient effects.
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Metformin
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Glimiperide
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Neutral insulin
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Glucagon
D
Correct answer
Explanation
Glucagon is the hyperglycemic agent among the options. It raises blood sugar levels by promoting glycogen breakdown in the liver. Metformin, glimiperide, and insulin are all hypoglycemic agents that lower blood sugar levels, making them incorrect choices for this question.
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Ibuprofen
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Acyclovir
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Erythromycin
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Dapsone
B
Correct answer
Explanation
Acyclovir is the specific antiviral drug used for herpes simplex virus (HSV) infections. It works by inhibiting viral DNA polymerase, preventing viral replication. Ibuprofen is an NSAID for pain and inflammation, erythromycin is an antibiotic for bacterial infections, and dapsone is used for leprosy and dermatitis herpetiformis - none are antivirals.
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Metformin
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Neutral Insulin
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Glipizide
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Glucagon
D
Correct answer
Explanation
With blood sugar at 56 mg/dL (severe hypoglycemia), glucagon is the most appropriate emergency treatment. Glucagon rapidly raises blood sugar by stimulating glycogenolysis in the liver. Metformin and glipizide are oral hypoglycemics that lower blood sugar - they would worsen the condition. Neutral insulin would dangerously lower blood sugar further.
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Nimesulide
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Penicillamine
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Gold
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Rofecoxib
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Osteoarthritis
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Rheumatoid Arthritis
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Ankylosing spondylitis
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None of the above
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Allopurinol
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Disulfirum
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Rifampicin
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Halothane
A
Correct answer
Explanation
Allopurinol is the most effective drug for gout treatment and prevention. It works by inhibiting xanthine oxidase, the enzyme that converts hypoxanthine to xanthine and xanthine to uric acid, thereby reducing uric acid production. Disulfiram is for alcohol aversion, rifampicin is an antibiotic (tuberculosis), and halothane is an inhalational anesthetic - none are gout medications.
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Nimesulide
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Acetaminophen
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Naproxen
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Doxepin
B
Correct answer
Explanation
The pharmacological (generic) name of paracetamol is acetaminophen. Paracetamol is the international nonproprietary name (INN) used in most countries, while acetaminophen is the generic name used primarily in the United States and Japan. Both refer to the same compound with analgesic and antipyretic properties.
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Nicotine
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Heroin
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Marijuana
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Cocaine
A
Correct answer
Explanation
Nicotine is the primary addictive alkaloid found naturally in tobacco leaves. Heroin, marijuana, and cocaine are entirely different drugs derived from other sources (opium poppy, cannabis plant, coca plant respectively) and are not naturally present in tobacco.
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Antidiuretic hormone
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Epinephrine and norepinephrine
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Atrial natriuretic peptide
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Angiotensin II
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Nicotine
C
Correct answer
Explanation
Atrial natriuretic peptide (ANP), a hormone secreted by the atria of the heart, lowers blood pressure by causing vasodilation and by stimulating the kidneys to excrete more water and Na+(lowering blood pressure by reducing blood volume).
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Chalone
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Ricin
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Oubain
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Lauryl sulfate
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Rifampicin
C
Correct answer
Explanation
Its mechanism of action involves its binding to and inhibition of the plasma membrane Na+/K+-ATPase (sodium pump) especially at the higher concentrations attainable in vitro or with intravenous dosage.
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Norethindrone
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Novestrol
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Equanil
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Novestrol and norethindrone
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Equanil and novestrol
A
Correct answer
Explanation
Norethindrone is an example of synthetic progesterone derivative most widely used as antifertility drug. The estrogen derivative, which is used in combination with progesterone derivative is ethynylestradiol (novestrol).
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mestranol
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ethinyl estradiol
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norethindrone
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drospirenone
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steviol
E
Correct answer
Explanation
Steviol glycosides are responsible for the sweet taste of the leaves of the stevia plant (Stevia rebaudiana Bertoni). These compounds range in sweetness from 40 to 300 times sweeter than sucrose. They are heat-stable, pH-stable, and do not ferment. They also do not induce a glycemic response when ingested, making them attractive as natural sweeteners to diabetics and others on carbohydrate-controlled diets.