Human Immunity and Blood

A form of T cell lymphoma with a characteristic dermatitis in a high proportion of patients.

Produce immunoglobulins of all isotypes including IgE.

Etanercept is the soluble TNF receptor. Infliximab is a monoclonal antibody - as indicated in the last part of the name InflixiMAB. TNF blockade can be achieved by either the use of a chimeric anti-TNF antibody (infliximab, adalimumab) or a soluble TNF receptor (etanercept).

Part of the pathway involved in IgE production, as well as involved in Th2 cellular responses.

These cells are the vital part of the cellular immune response, destroying the cells which bears any foreign antigen on their surface, mainly virus-infected cells.

Basophils are involved in allergic reactions and release histamine (for triggering inflammation) and heparin (for preventing blood clotting).

Eosinophils accumulate in the nasal mucosa during allergic rhinitis. Accumulation of eosinophils in the nasal mucosa is considered a major diagnostic criterion for allergic rhinitis (nasal allergies).

Cytotoxic T-cells cause lysis of virally infected cells, tumour cells and allografts.

Alkaline phosphatase, lysozyme, NADPH oxidase, collagenase, lactoferrin and cathelicidin are contained in the specific granules (or secondary granules) of neutrophils.

In classical complement pathway, C4b2b complex functions as C3 convertase. It cleaves C3 into C3a and C3b.

The classical complement pathway typically requires antigen-antibody complexes (immune complexes) for activation (specific immune response).

C7 protein is associated with a transition of the complex from a hydrophilic to hydrophobic state and allows complex to insert itself into the lipid bilayer.

This is incorrect. Presence of lymphocytes in tumours is often associated with better clinical outcomes.

Granzymes function as serine proteases. They supposedly bring about protein lysis and DNA damage.

Alpha-2-macroglobulin inhibits coagulation by inhibiting thrombin. It also inhibits fibrinolysis by inhibiting plasmin.