Multiple choice

Cryptic T-cell epitopes are capable of triggering autoimmune diseases in human beings. Which among the following statements regarding the cryptic T-cell epitopes is correct?

  1. They dominate the normal immune response.

  2. They negatively select T-cells.

  3. They are unable to bind in the MHC groove.

  4. They can be derived by antigen processing.

  5. They are presented by MHC class I but not MHC class II molecules.
Reveal answer Fill a bubble to check yourself
D Correct answer
Explanation

In order to be T-cell epitopes, i.e. peptides, they must be derived by antigen processing. Qualitative and/or quantitative alterations in processing can lead to greatly increased production of cryptic peptides and thus, may trigger autoimmune disease.

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