Multiple choice

Which of the following statements characterises a peptide immunogen?

  1. It can mimic a part of a discontinuous epitope.

  2. It adopts a single rigid structure in solution.

  3. It can elicit potent antibody responses in the absence of T-cell help.

  4. It can be used to stimulate B-cell, but not T-cell responses.

  5. Lack of contact residues capable of interacting with the antigen receptor on the relevant lymphocytes.
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A Correct answer
Explanation

Although a single peptide sequence, being a linear array of amino acids, by definition cannot fully represent a discontinuous epitope, it can comprise a part of such an epitope. However, because the epitope is incomplete, the peptide would probably only generate antibodies that have a relatively low affinity for the native antigen.

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