Multiple choice

A vaccine is a biological preparation that improves immunity to a particular disease. Why would a small protein subunit used in a vaccine fail to stimulate T-cell immunity?

  1. Because of an inherently insufficient antigen concentration.

  2. Because of a lack of carrier determinants.

  3. Because of HLA-related unresponsiveness.

  4. Because of a lack of glycosylation.

  5. Because of a lack of conformation.
Reveal answer Fill a bubble to check yourself
C Correct answer
Explanation

A major concern about subunit vaccines, especially when just short peptides are used, is the variation in ability to associate with the different polymorphic forms of MHC molecules present in an outbred population.

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