Multiple choice

A subunit vaccine makes use of just a small portion of a pathogen. A small protein subunit used in a vaccine may fail to stimulate T-cell immunity because of the

  1. lack of glycosylation

  2. lack of conformation

  3. lack of carrier determinants

  4. HLA-related unresponsiveness

  5. inherently insufficient antigen concentration
Reveal answer Fill a bubble to check yourself
D Correct answer
Explanation

A major concern about subunit vaccines, especially when just short peptides are used, is the variation in ability to associate with the different polymorphic forms of MHC molecules present in an outbred population.

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