Multiple choice Which of the following cannot bypass the T-helpers? Failure of regulatory T-cells Polyclonal activation of B-cells Idiotypic mechanisms Antigenic cross-reaction T-cell recognition of carrier complexed to autoantigen Reveal answer Fill a bubble to check yourself A Correct answer Explanation Failure of regulatory T-cells would release the T-helper for direct stimulation by antigen. This statement is therefore incorrect, since this would not be a bypass of the T-helpers.