Multiple choice

Cryptic T-cell epitopes

  1. dominate the normal immune response

  2. negatively select T-cells

  3. are unable to bind in the MHC groove

  4. can be derived by antigen processing

  5. are presented by MHC class I, but not MHC class II molecules
Reveal answer Fill a bubble to check yourself
D Correct answer
Explanation

In order to be T-cell epitopes, i.e. peptides, they must be derived by antigen processing. Qualitative and/or quantitative alterations in processing can lead to greatly increased production of cryptic peptides and thus, may trigger autoimmune disease.

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