Multiple choice

Immunoproteasome is a protease abundant in immune cells. Which of the following statements does not characterises the immunoproteasome?

  1. It is generated in response to interferon-gamma stimulation.

  2. It contains the nonpolymorphic MECL1 subunit.

  3. It contains the polymorphic LMP7 subunit.

  4. Ten per cent of the peptides generated are 8–9 residues in length.

  5. It exhibits both chymotrypsin-like and trypsin-like activities.
Reveal answer Fill a bubble to check yourself
D Correct answer
Explanation

About ten per cent of the peptides generated by the housekeeping proteasome are 8–9 residues in length, but the immunoproteasome is thought to be specialized to produce a greater proportion of peptides of this length which is optimal for insertion into the MHC class I groove.

Keep practicing — related questions