Multiple choice

The HIV nef protein affects antigen presentation by which of the following?

  1. Causing MHC class I endocytosis.

  2. Containing glycine-alanine repeats, which inhibit proteasome-mediated processing of the virus.

  3. Preventing peptide binding to TAP.

  4. Preventing peptide transport through the TAP pore.

  5. Competing for peptide binding to the MHC class I heavy chain.
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A Correct answer
Explanation

It thereby prevents effective presentation of antigen peptides to the T-cell receptor.

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