Multiple choice

In a person suffering from AIDS, the HIV nef protein affects antigen presentation mainly by

  1. causing MHC class I endocytosis

  2. containing glycine-alanine repeats which inhibit proteasome-mediated processing of the virus

  3. preventing peptide binding to TAP

  4. preventing peptide transport through the TAP pore

  5. competing for peptide binding to the MHC class I heavy chain
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A Correct answer
Explanation

it thereby prevents effective presentation of antigen peptides to the T-cell receptor

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