Multiple choice

Match List - A (antibiotics), List - B (classes) and List - C (mechanism of action) and select the correct answer using the codes given below in the lists.

   
List - A
List - B
List - C
P. Amikacin 1. oxazolidonone i. inhibiting translocation of peptidyl-tRNA
Q. Loracarbef 2. aminoglycosides ii. inhibiting protein synthesis
R. Cephalexin 3. carbacephem iii. inhibiting peptidoglycan layer synthesis
S. Linezolid 4. first generation cephalosporin iv. inhibiting cell wall synthesis

  1. P - 3 - i, Q - 2 - iv, R - 4 - iii, S - 1 - ii

  2. P - 2 - i, Q - 3 - iv, R - 1 - iii, S - 4 - ii

  3. P - 2 - i, Q - 3 - ii, R - 1 - iii, S - 4 - iv

  4. P - 2 - i, Q - 3 - iv, R - 1 - ii, S - 4 - iii

  5. P - 2 - i, Q - 3 - iv, R - 4 - iii, S - 1 - ii

Reveal answer Fill a bubble to check yourself
E Correct answer
Explanation

Amikacin belongs to aminoglycosides. Binding to the bacterial 30S ribosomal sub-unit inhibits the translocation of the peptidyl-tRNA from the A-site to the P-site. Loracarbef is carbacephem antibiotic. It prevents bacterial cell division by inhibiting cell wall synthesis. Cephalexin is the first generation cephalosporin and it disrupts the synthesis of the peptidoglycan layer of bacterial cell walls. Linezolid belongs to oxazolidonone class and this is a protein synthesis inhibitor that prevents the initiation step. Hence, the correct answer is P - 2 - i, Q - 3 - iv, R - 4 - iii, S - 1 - ii.