Multiple choice

Match the antibiotics with their mechanism of action.

 
Antibiotic MOA
1. Polymyxin B a. Cross linking of DNA
2. Enoxacin b. Disrupts cell membrane function
3. Furazolidone c. Alters bacterial outer membrane permeability
4. Daptomycin d. Inhibits bacterial gyrase

  1. 1. Polymyxin B b. Disrupts cell membrane function
    2. Enoxacin a. Cross linking of DNA
    3. Furazolidone c. Alters bacterial outer membrane permeability
    4. Daptomycin d. Inhibits bacterial gyrase
  2. 1. Polymyxin B c. Alters bacterial outer membrane permeability
    2. Enoxacin d. Inhibits bacterial gyrase
    3. Furazolidone a. Cross linking of DNA
    4. Daptomycin b. Disrupts cell membrane function
  3. 1. Polymyxin B d. Inhibits bacterial gyrase
    2. Enoxacin b. Disrupts cell membrane function
    3. Furazolidone c. Alters bacterial outer membrane permeability
    4. Daptomycin a. Cross linking of DNA
  4. 1. Polymyxin B d. Inhibits bacterial gyrase
    2. Enoxacin a. Cross linking of DNA
    3. Furazolidone b. Disrupts cell membrane function
    4. Daptomycin c. Alters bacterial outer membrane permeability
Reveal answer Fill a bubble to check yourself
B Correct answer
Explanation

This is the correct match. Polymyxin B alters bacterial outer membrane permeability by binding to a negatively charged site in the lipopolysaccharide layer and destabilises the outer membrane. Enoxacin functions by inhibiting bacterial DNA gyrase and topoisomerase IV and prevents bacterial DNA replication, transcription, repair and recombination. Furazolidone works by crosslinking of DNA. Daptomycin disrupts multiple aspects of bacterial cell membrane function which results in bacterial cell death.

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