Multiple choice

Match compounds in Group I with inhibitory activities in Group II.

Group – I
Group – II
A. Chloramphenicol 1. Protein synthesis
B. Rifampin 2. RNA synthesis
C. Sulfadiazine 3. Folate synthesis
D. Vancomycin 4. Cell wall synthesis

  1. A - 1, B - 2, C - 3, D - 4

  2. A - 1, B - 3, C - 2, D - 4

  3. A - 2, B - 1, C - 4, D - 3

  4. A - 2, B - 3, C - 4, D - 1

  5. A - 3, B - 4, C - 2, D - 1
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A Correct answer
Explanation

Chloramphenicol is lipid-soluble and can easily diffuse through the bacterial cell membrane. It then reversibly binds to the L16 protein of the 50S subunit of bacterial ribosomes and prevents the transfer of amino acids to growing peptide chains. Thus, inhibits peptide bond formation and subsequent protein synthesis. Rifampin acts via the inhibition of DNA-dependent RNA polymerase, leading to a suppression of RNA synthesis and cell death. Sulfadiazine acts by Folate synthesis inhibition. It is a competitive inhibitor of the bacterial enzyme dihydropteroate synthetase needed for the proper processing of para-aminobenzoic acid (PABA) which is essential for folic acid synthesis. The inhibited reaction is necessary in these organisms for the synthesis of folic acid. Vancomycin acts by inhibiting proper cell wall synthesis in Gram-positive bacteria.

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