Multiple choice general knowledge history The First battle of Panipat was fought between: Sikandar Lodi and Humayun Ibrahim Lodi and Babar Sikandar Lodi and Babar Ibrahim Lodi and Humayun Reveal answer Fill a bubble to check yourself B Correct answer Explanation The First Battle of Panipat (1526) was fought between Ibrahim Lodi (the last Lodi dynasty ruler of Delhi) and Babur (the founder of the Mughal Empire). Babur's victory marked the beginning of Mughal rule in India.