Multiple choice

Antigenic shift is seen only with influenza A viruses. It results usually from the replacement of the hemagglutinin and generally involves

  1. single point mutation

  2. random point mutations

  3. interchanging of large segments of the viral genome with other viruses

  4. rearrangement of the viral structural architecture

  5. regression to an earlier variant
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C Correct answer
Explanation

The ability to interchange large segments of the genome with a viral reservoir in other animal species is the basis of antigenic shift leading to radical change in antigen, particularly crucial antigens giving protective immunity such as the viral hemagglutinin.

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