Multiple choice

Streptococcus pyogenes owes its major success as a pathogen to its ability to colonise and rapidly multiply and spread in its host while evading phagocytosis and confusing the immune system. Which among the following statements is correct regarding the pyrogenic streptococcal exotoxins SPE, A, B and C?

  1. They are M proteins.

  2. They cause post-streptococcal autoimmune disease.

  3. They produce high titers of anti-streptolysin O.

  4. They have hyaluronidase activity.

  5. They are superantigens.
Reveal answer Fill a bubble to check yourself
E Correct answer
Explanation

The superantigens combine with the framework regions of certain TCR V beta families irrespective of their complementarity determining regions.

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