Multiple choice The pyrogenic streptococcal exotoxins SPE, A, B, and C ____________. are M proteins cause post-streptococcal autoimmune disease produce high titers of anti-streptolysin O have hyaluronidase activity are superantigens Reveal answer Fill a bubble to check yourself E Correct answer Explanation The superantigens combine with the framework regions of certain TCR V beta families irrespective of their complementarity determining regions.