Multiple choice

Which of the following is caused by mutation in merlin (tumor suppressor) gene?

  1. Neurofibromatosis type I

  2. Neurofibromatosis type II

  3. Miller-Dieker syndrome

  4. Smith-Magenis syndrome
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B Correct answer
Explanation

Neurofibromatosis type (NF-II) is caused by mutations of the merlin gene. The main manifestation of the disease is the development of symmetric, non-malignant brain tumors in the region of the cranial nerve VIII, which is the auditory-vestibular nerve that transmits sensory information from the inner ear to the brain.

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