Multiple choice

Developmental anomalies associated with basal cell nevus syndrome are believed to occur as a result of

  1. homozygous mutation of a tumor suppressor gene

  2. gain of function mutation

  3. haploinsufficiency

  4. loss-of-function mutation

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C Correct answer
Explanation

Haploinsufficiency is believed to explain the developmental anomalies, whereas tumors form as a consequence of homozygous mutation by a tumor suppressor mechanism.