Multiple choice

The protein coded by a tumour suppressor gene in humans

  1. forms fractions of a growth factor signaling pathway

  2. codes for a DNA repair enzyme

  3. helps to prevent apoptosis

  4. controls progression through the cell cycle
Reveal answer Fill a bubble to check yourself
D Correct answer
Explanation

Tumour suppressor genes code for proteins, which normally control progression through a cell cycle checkpoint. These genes only contribute to a cancer when both copies are mutated in a way which produces an inactive protein product. A single mutation inactivating only one gene has no effect. They contribute to cancer because the absence of the protein product removes controls on cell division.

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