Multiple choice

Which of the following does not characterise the tumor suppressor genes?

  1. Transmitted as dominant traits in families

  2. May be associated with loss of heterozygosity in tumors.

  3. Act dominantly in tumor cells.

  4. Associated with two-hit model of carcinogenesis.
Reveal answer Fill a bubble to check yourself
C Correct answer
Explanation

Tumor suppressor gene mutations are transmitted in a dominant manner in families, but act recessively in tumor cells,which is why two hits are required in the tumor.

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