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Mixed Biology Test

This test is based on certain topics from biology which is beneficial for learning aspirants.

25 Questions Published
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Questions

Question 1 Multiple Choice (Single Answer)

Which of the following repeated sequences includes an open reading frame for reverse transcriptase?

  1. LINE
  2. SINE
  3. Segmental duplications
  4. DNA transposons
Question 2 Multiple Choice (Single Answer)

A study of a disorder reveals that monozygotic twins are concordant 40% of the time, whereas full siblings are concordant 10% of the time. Which of the following is the best interpretation of this finding?

  1. The trait has no genetic component.
  2. The trait is completely determined by genetics.
  3. Genes contribute to the trait, but are not deterministic.
  4. The trait must be due to the biology of twinning.
Question 3 Multiple Choice (Single Answer)

Which of the following best explains the threshold model?

  1. A quantitative multifactorial trait
  2. A polygenic multifactorial trait
  3. A multifactorial trait results in a non-disease phenotype such as height
  4. A multifactorial trait exhibits all or none phenotype.
Question 4 Multiple Choice (Single Answer)

In meiosis, when do homologous chromosomes begin to pair?

  1. Prophase I
  2. Metaphase I
  3. Metaphase II
  4. Prophase II
Question 5 Multiple Choice (Single Answer)

The purpose of adding phytohemagglutinin to peripheral blood cultures for chromosomal analysis is

  1. swelling of cells to permit chromosome visualization
  2. collection of large number of cells at metaphase
  3. chromosome condensation
  4. stimulation of lymphocyte cell division
Question 6 Multiple Choice (Single Answer)

Which among the following statements signifies the 47,XX, +13 karyotype designation?

  1. A female with 13 extra chromosomes
  2. A female with trisomy 13
  3. A male with trisomy 13
  4. A female with extra material on chromosome 13
Question 7 Multiple Choice (Single Answer)

Alpha satellite DNA is preferentially localized at

  1. telomeres
  2. stalks of acrocentric chromosomes
  3. centromeres
  4. dark G-bands
Question 8 Multiple Choice (Single Answer)

A multifactorial trait occurs more often in females than males. A couple have an affected son. Which of the following is true regarding their risk of recurrence?

  1. Recurrence is higher if they had an affected daughter, and is most likely for a future son.
  2. Recurrence is higher if they had an affected daughter, and is most likely for a future daughter.
  3. Recurrence is lower if they had an affected daughter, and is most likely for a future son.
  4. Recurrence is lower if they had an affected daughter, and is most likely for a future daughter.
Question 9 Multiple Choice (Single Answer)

Which of the following is not true of G-light bands?

  1. They fluorescence brightly with quinacrine
  2. They are GC-rich
  3. They are rich in expressed genes.
  4. They are loosely packed.
Question 10 Multiple Choice (Single Answer)

Molecular analysis is performed on the three copies of chromosome 21 in a child with Down syndrome using DNA polymorphisms for which both parents are heterozygous for different alleles. Two of the chromosomes contain same alleles as one of the mother's alleles. Based on this, when did the nondisjunction event most likely occur?

  1. Maternal meiosis I
  2. Maternal meiosis II
  3. Paternal meiosis I
  4. Paternal meiosis II
Question 11 Multiple Choice (Single Answer)

Which of the following syndromes is associated with Uniparental disomy for chromosome 15 in which both chromosomes are maternally derived?

  1. Prader-Willi syndrome
  2. Angelman syndrome
  3. Rett syndrome
  4. Beckwith-Wiedemann syndrome
Question 12 Multiple Choice (Single Answer)

The one factor known to be associated with nondisjunction is

  1. radiation exposure
  2. advanced maternal age
  3. advanced paternal age
  4. alcohol exposure
Question 13 Multiple Choice (Single Answer)

Which of the following is not a postulate of the Hardy-Weinberg equilibrium?

  1. No mutation
  2. No more than two alleles at a locus
  3. Random mating with respect to genotype.
  4. No selection on basis of genotype.
Question 14 Multiple Choice (Single Answer)

Deviation from the Hardy-Weinberg assumption of infinitely large population size results in

  1. genetic lethal
  2. heterozygote advantage
  3. consanguinity
  4. genetic drift
Question 15 Multiple Choice (Single Answer)

A balanced polymorphism occurs when

  1. there is selection against the homozygous recessive individuals
  2. there is selection against heterozygotes
  3. there is selection against all genotypes
  4. there is selection against all homozygotes
Question 16 Multiple Choice (Single Answer)

Which of the following is most likely to prevent extinction of a rare allele in which homozygosity represents a genetic lethal?

  1. New mutation
  2. Genetic drift
  3. Founder effect
  4. Balanced polymorphism
Question 17 Multiple Choice (Single Answer)

Which of the following is required to see a founder effect?

  1. Population bottleneck in which the population is reduced to a relatively small number of breeding individuals.
  2. It is not associated with genetic drift.
  3. It cannot lead to the speciation and subsequent evolution of new species.
  4. Serial founder effects have occurred when populations migrate over long distances.
Question 18 Multiple Choice (Single Answer)

If two populations are merged, each with different frequencies of an allele at a locus, and randomly mating occurs immediately, how long will it take to achieve a Hardy-Weinberg equilibrium in the new population?

  1. One generation
  2. Ten generations
  3. Variable depends on allele frequencies
  4. The population will never achieve equilibrium.
Question 19 Multiple Choice (Single Answer)

The translocation of chromosomes 9 and 22 is a characteristic of

  1. Kaposi's sarcoma
  2. Li-Fraumeni syndrome
  3. Chronic myelogenous leukemia
  4. OSLAM syndrome
Question 20 Multiple Choice (Single Answer)

Which of the following does not characterise the tumor suppressor genes?

  1. Transmitted as dominant traits in families
  2. May be associated with loss of heterozygosity in tumors.
  3. Act dominantly in tumor cells.
  4. Associated with two-hit model of carcinogenesis.
Question 21 Multiple Choice (Single Answer)

Which among the following explanations regarding the proto-oncogenes is NOT true?

  1. These genes are produced by somatic mutations induced by carcinogenic substances.
  2. These genes also code for proteins associated with cell growth.
  3. Some are activated by gene amplification.
  4. They are originally derived from RNA tumor viruses.
Question 22 Multiple Choice (Single Answer)

The phase of mitosis during which chromosomes condense is

  1. prophase
  2. telophase
  3. metaphase
  4. anaphase
Question 23 Multiple Choice (Single Answer)

Double minute chromatin bodies are indicative of which of the following?

  1. Translocations
  2. Gene amplification
  3. Apoptosis
  4. Inactivation of a tumor suppressor gene
Question 24 Multiple Choice (Single Answer)

Genes responsible for hereditary nonpolyposis colon cancer encode proteins with which of the following functions?

  1. DNA mismatch repair
  2. Cell membrane receptor
  3. Transcription factor
  4. Cell cycle control
Question 25 Multiple Choice (Single Answer)

Consider a family where both father and son have retinoblastoma. DNA analysis from the child's tumor shows only a single allele from the Rb locus on chromosome 13. Both parents are heterozygous in blood, as is the child. Which allele would you expect is preserved in the tumor?

  1. Mother's
  2. Father's
  3. There is a 50:50 chance that it is the mother's or father's allele.
  4. Both alleles would be abnormal due to genetic rearrangement.
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