Tag: zoology

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Questions Related to zoology

Multiple choice zoology genetics of the future gene therapy application of biology in therapy and vaccine gene cloning

What might be an advantage of beginning gene therapy prior to birth? 

  1. This would give the body plenty of time to utilize the new genes.

  2. The body would not reject it as it has not yet recognized 'self'.

  3. The cells being extremely young. are more receptive of gene therapy.

  4. There probably is not any advantage.
Reveal answer Fill a bubble to check yourself
B Correct answer
Explanation

Gene therapy is a newly emerging branch of biotechnology with tremendous results. It is basically used for correcting genetic disorders. In gene therapy, normal genes are introduced in the cells to replace the missing genes or defective genes. 

Early gene therapy has been proved to be more effective in treating certain brain diseases in humans. They have also shown exemplary results in mice.  
When a child is born, he has its innate immunity, which does not allow any foreign body to settle into its own body easily. But before birth, it has not yet recognized itself, so therapy would be easily accepted.
So the correct answer is B.

Multiple choice zoology genetics of the future gene therapy application of biology in therapy and vaccine gene cloning

The method of correcting the defective genes is called

  1. genetic engineering

  2. gene therapy

  3. somatic hybridization

  4. protoplast fusion
Reveal answer Fill a bubble to check yourself
B Correct answer
Explanation
The use of bioengineered cells and biological techniques to treat human genetic disorder is known as gene therapy. Gene therapy is the transfer of a normal gene into body cells to correct the genetic defect. It can be used to treat genetic diseases like sickle cell anaemia and SCID.
The SCID patients have no functioning t lymphocytes and one treated with injections of the white blood cells that have been engineered to carry the normal ADA alleles.
So, the correct option is 'gene therapy'
Multiple choice zoology genetics of the future gene therapy application of biology in therapy and vaccine gene cloning

Which kind of therapy was given in $1990$ to a four-year-old girl with Adenosine Deaminase(ADA) deficiency?

  1. Gene therapy

  2. Chemotherapy

  3. Immunotherapy

  4. Radiation therapy
Reveal answer Fill a bubble to check yourself
A Correct answer
Explanation

First successful gene transfer in human was performed by F.Anderson. Ashi Disilva a 4-year girl was treated by replacing ADA gene in lymphocytes.

The girl was suffering from Severe Combined Immunodeficiency (SCID). Gene therapy was used for the treatment of ADA deficiency.
So, the correct option is 'Gene therapy'.

Multiple choice zoology applications of biotechnology gene therapy application of biology in therapy and vaccine gene cloning

A correction or alleviation of a genetic disorder by the introduction of a normal gene copy into an affected individual is called as

  1. Gene probe

  2. Gene multiplication

  3. Gene therapy

  4. Gene cloning
Reveal answer Fill a bubble to check yourself
C Correct answer
Explanation

Gene cloning is the process of making the copies of gene of interest by locating it in DNA followed by extraction of DNA containing that gene. A probe is a radiolabeled single-stranded DNA/ RNA fragment used to search for a gene of interest or other DNA sequence. For the purpose, the base sequence of probe is complementary to the target sequence to facilitate its base pairing with target gene. Gene multiplication is a mechanism that increase the genes in their number of copies. It is also called as gene amplification and is the source of evolution. Gene therapy is the process of introduction of DNA into living human beings in order to treat disease. It is used to replace a missing gene product or to correct mutant alleles. Correct answer is C.

Multiple choice zoology applications of biotechnology gene therapy application of biology in therapy and vaccine gene cloning

Immune deficiency disorder, which occur due to mutation in gene, involved in maturation of T and B lymphocytes is

  1. IDDM

  2. Hashimoto disease

  3. SCID

  4. Pernicious anemia
Reveal answer Fill a bubble to check yourself
C Correct answer
Explanation

  • Insulin-Dependent Diabetes Mellitus or IDDM is an immune deficiency disorder. It occurs due to a mutation in a gene involved in insulin-producing β cells in the pancreas. 
  • Hashimoto's disease is an autoimmune disorder that results in hypothyroidism. It results in defects in the maturation of T lymphocytes. 
  • Severe combined immunodeficiency (SCID) is an immunodeficiency syndrome. It occurs due to a mutation in the gene involved in the maturation of T and B lymphocytes. 
  • Pernicious anemia is also called as vitamin B$ _{12}$ deficiency syndrome. It results due to a lack of intrinsic factor. 
Thus, the correct answer is 'Hashimoto disease and SCID.'

Multiple choice zoology applications of biotechnology gene therapy application of biology in therapy and vaccine gene cloning

"Introduction of a normal functional gene into cells, in order to replace defective or mutated gene'." is known as 

  1. Biosafety

  2. Biopiracy

  3. Biopatent

  4. Gene therapy
Reveal answer Fill a bubble to check yourself
D Correct answer
Explanation

Introduction of a normal functional gene into cells, in order to replace defective or mutated gene is known as gene therapy. It is also called as gene transfer. It is done to correct genetic disorders. Biosafety is the prevention of large-scale loss of biological integrity. Biopiracy is the practice of exploiting indigenous knowledge of nature, originating with indigenous peoples without compensation to the indigenous people. Biopatent is a patent granted by the government to the inventor of biological entities.

Thus, the correct answer is 'Gene therapy.'

Multiple choice zoology applications of biotechnology gene therapy application of biology in therapy and vaccine gene cloning

a functional ADAcDNA can be introduced into cells of the patients receiving gene therapy by using vector constituted by

  1. E.coil

  2. Reoviridae

  3. Retrovirus

  4. Agrobacterium
Reveal answer Fill a bubble to check yourself
A Correct answer
Explanation
The deficiency of the purine salvage enzyme adenosine deaminase is associated with severe B and T-cell dysfunction. In order to investigate the ADA molecule, gene therapy using E.coli, cDNA clones encoding ADA gene sequences are obtained.
So the correct option is 'E.coli'.
Multiple choice zoology applications of biotechnology gene therapy application of biology in therapy and vaccine gene cloning

Cystic fibrosis can be treated by .......... gene therapy.

  1. TGP-B

  2. TPA

  3. DNase

  4. BGH
Reveal answer Fill a bubble to check yourself
C Correct answer
Explanation

DNase (Deoxyribonuclease) is used in cystic fibrosis treatment to break down the thick mucus in the lungs, which is rich in DNA from dead white blood cells. While gene therapy is a research area for cystic fibrosis, DNase is the standard pharmacological treatment listed.