Tag: health and diseases

 Polycythemia is a disease state in which the hematocrit (the volume % of RBC in the Blood) is elevated.It can be due to an increase in the number of RBC ("absolute polycythemia") or to a decrease in the volume of plasma ("relative polycythemia").

'Philadelphia chromosome' is found in the patient suffering from leukaemia. The main cause is a genetic abnormality in chromosome 22 of leukaemia cancer cells. The chromosome is short due to a reciprocal translocation between chromosome 9 and chromosome 22 and contains a fusion gene called BCR-ABL1 which is juxtaposed onto the BCR gene of chromosome 22, coding for a hybrid protein, a tyrosine kinase signalling protein which causes rapid multiplication of the cell.

Oncogenes are genes that has the potential to cause cancer.
Estrogens are a group of hormones that are important for female sexual and reproductive development.
Carcinogens are substances, radionuclide or radiation that is an agent directly involved in causing cancer.
Therefore, the correct answer is option D.

The spread of tumour cells through vascular system (blood, lymph) from the site of formation to other parts of the body is known as metastasis.

The ozone layer is present in the stratosphere above the Earth. The layer of ozone is responsible for the absorption of the harmful ultraviolet radiations from the solar radiations. These radiations are prevented from entering the Earth's atmosphere to prevent the development of skin cancer. The radiations can also damage the eye and other exposed parts of the body. 

Carcinogen is a substance or agent that can cause cells to become cancerous by altering their genetic structure so that they multiply continuously and become malignant. Asbestos, DDT, and tobacco smoke are examples of carcinogens.

Cancer arises from the abnormal, purposeless, and uncontrolled division of cells that then invade and destroy the surrounding tissues.

Cell cycles are regulated by cyclins and Cyclin dependent kinases (CDK). In cancer cells this regulatory mechanism is lost, thus the cells divide or proliferate in an uncontrolled manner after a certain stage, they produce growth factors and respond to them in an autocrine manner. Since, they are the body cells they are not destroyed by the immune system. They are capable of separating from the parent tumor and establishing else where in the body, a process called metastasis.

Saccharin is a artificial sweetener. It is thermostable and remains inert at high temperature. It was discovered in 1879. It helps to control weight and its good for diabetes patients. It was used as sugar substitute in place of sucrose. It has been discontinued because it was considered a carcinogenic agent by FDA.