Leonardo da Vinci painted 'John the Baptist' in the early 16th century. It depicts John the Baptist in solitude, with a pointing gesture and enigmatic smile characteristic of da Vinci's later works. 'Madonna of the Meadow' is by Raphael, 'Boy Bitten by a Lizard' is by Caravaggio, and 'Creation of Adam' is Michelangelo's famous Sistine Chapel fresco.