Multiple choice

Which one of the following forms of the same DNA molecule would bind maximum ethidium bromide?

  1. Negatively supercoiled

  2. Covalently closed relaxed circle

  3. Linear

  4. Positively supercoiled

Reveal answer Fill a bubble to check yourself
A Correct answer
Explanation

Ethidium bromide intercalates into DNA, causing unwinding. Negatively supercoiled DNA has more space for intercalation compared to relaxed or positively supercoiled DNA, allowing it to bind more dye.