Multiple choice Work of Beadle and Tautum on Neurospora crassa proved that replication of DNA is semi-conservative viruses have genetic material every gene is responsible for specific enzymes plant cells are totipotent - Reveal answer Fill a bubble to check yourself C Correct answer Explanation The one gene-one enzyme hypothesis is the idea that genes act through the production of enzymes, with each gene responsible for producing a single enzyme that in turn affects a single step in a metabolic pathway. This was proved by Beadle and Tatum.