Multiple choice

Who among the following experimentally demonstrated that DNA replication is semi-conservative?

  1. Sutton and Boveri

  2. Meselson and Stahl

  3. Griffth

  4. Hershey and Chase
Reveal answer Fill a bubble to check yourself
B Correct answer
Explanation

Meselson and Stahl (1958) experimentally demonstrated semi-conservative DNA replication using density gradient centrifugation with nitrogen isotopes (N-14 and N-15). They grew E. coli in heavy N-15 medium, then transferred to light N-14 medium. After each generation of replication, DNA showed intermediate density (one heavy and one light strand), proving semi-conservative replication. Sutton and Boveri worked on chromosome theory, Griffith discovered transformation, and Hershey-Chase proved DNA is genetic material.

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