Multiple choice Which gland in the human body is called the master gland? Spleen Pituitary Thyroid Pancreas Reveal answer Fill a bubble to check yourself B Correct answer Explanation The pituitary gland is sometimes called the master gland of the endocrine system, because it controls the functions of the other endocrine glands. The pituitary gland is no larger than a pea, and is located at the base of the brain.