Multiple choice

Brefeldin A is a lactone antibiotic produced by fungal organisms such as Eupenicillium brefeldianum. It is used to check the activity of which of the following cell organelles?

  1. Mitochondria

  2. Nucleus

  3. Golgi apparatus

  4. Endoplasmic reticulum

Reveal answer Fill a bubble to check yourself
C Correct answer
Explanation

Brefeldin A is used to test Golgi function. It blocks the activation of some ADP-ribosylation factors (ARFs) which regulate vesicular trafficking through the binding of COPs to the Golgi. Thus, treatment with Brefeldin A disrupts the secretion pathway.