Which among the following is required for transferring specific immunity to M. tuberculosis in mice?
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B-cells
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T-cells
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Macrophages
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Neutrophils
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IgG
B
Correct answer
Explanation
T-cells are important for immunity to M. tuberculosis through the provision of Th1 cytokines such as IFN-gamma to activate macrophages containing the bacilli and perhaps also the participation of cytotoxic T-cells. The latter may kill macrophages which cannot be rescued by cytokines thereby releasing the bacteria to be taken up by fresh young macrophages which can be activated to become killers.