Multiple choice

Which among the following is required for transferring specific immunity to M. tuberculosis in mice?

  1. B-cells

  2. T-cells

  3. Macrophages

  4. Neutrophils

  5. IgG

Reveal answer Fill a bubble to check yourself
B Correct answer
Explanation

T-cells are important for immunity to M. tuberculosis through the provision of Th1 cytokines such as IFN-gamma to activate macrophages containing the bacilli and perhaps also the participation of cytotoxic T-cells. The latter may kill macrophages which cannot be rescued by cytokines thereby releasing the bacteria to be taken up by fresh young macrophages which can be activated to become killers.