Multiple choice

Mutations in the genes for the hemoglobin protein in a particular species leads to the formation of hemoglobin variants. Which of the following genetic disorders is caused by mutation in the haemoglobin gene?

  1. Haemophilia

  2. Tay-Sachs disease

  3. Sickle-cell disease

  4. Cystic fibrosis

  5. Phenylketonuria

Reveal answer Fill a bubble to check yourself
C Correct answer
Explanation

Sickle-cell disease is a hereditary blood disorder, characterised by red blood cells that assume an abnormal, rigid and sickle shape. Sickling decreases the cells' flexibility and results in a risk of various life-threatening complications. This sickling occurs because of a mutation in the haemoglobin gene.