Mutations in the genes for the hemoglobin protein in a particular species leads to the formation of hemoglobin variants. Which of the following genetic disorders is caused by mutation in the haemoglobin gene?
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Haemophilia
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Tay-Sachs disease
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Sickle-cell disease
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Cystic fibrosis
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Phenylketonuria
C
Correct answer
Explanation
Sickle-cell disease is a hereditary blood disorder, characterised by red blood cells that assume an abnormal, rigid and sickle shape. Sickling decreases the cells' flexibility and results in a risk of various life-threatening complications. This sickling occurs because of a mutation in the haemoglobin gene.