Multiple choice

Which of the following genetic disorders results from nonsense mutation?

  1. Sickle cell anemia

  2. Thalassemia

  3. Cystic fibrosis

  4. Fragile X syndrome

  5. Huntington's disease
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B Correct answer
Explanation

In genetics a nonsense mutation is a point mutation in a sequence of DNA that results in a premature stop codon or a nonsense codon in the transcribed mRNA and in a truncated, incomplete and usually nonfunctional protein product. It differs from a missense mutation which is a point mutation where a single nucleotide is changed to cause substitution of a different amino acid. Some genetic disorders such as thalassemia and DMD result from nonsense mutations.

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