Multiple choice Which virus causes Progressive Multifocal Leukoencephalopathy? BK virus JC virus TBE virus B19 virus Reveal answer Fill a bubble to check yourself B Correct answer Explanation Progressive Multifocal Leukoencephalopathy (PML) is a disease of the white matter of the brain, caused by JC (John Cunningham) virus infection that targets cells that make myelin - the material that insulates nerve cells (neurons).